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Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. If you have ly obtained access with your personalplease log in. In the first sense, cyclopenthiazide is more potent than frusemide, and in the second sense the reverse is true. Potency cannot be measured in precise and absolute terms without detailed specification of the method of measurement, and then it becomes an excessively arbitrary measurement.
Relative potency is more easily determined, but it also is Drug strength definition according to the circumstances in which it is assessed. An approximate estimate of potency is afforded by the dose ordinarily used therapeutically. For some groups of drugs, variation in effective dose is enormous and for others, quite small. The causes of such variations are not well known, but probably involve the cumulation of several separate factors.
Differences in maximal effect generally indicate a different mode of action and raise doubts about the strict comparability of the drugs concerned. Such differences have definite therapeutic utility. Otherwise high potency in the sense of small effective dosage has some advantages and some disadvantages to a therapist and is, at best, a minor merit in most circumstances.
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