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Compare nonpharmacological and pharmacological interventions in adult women with urinary incontinence. Guided Tour! It does not reanalyze the evidence and, thus, has the same limitations presented in the report. In its current form, the tool is not intended to aid decision making, nor does it provide or allow for additional analyses not included in the original report. Start Tutorial No thanks Do not show this again. Key Messages Available non-pharmacological and pharmacological interventions generally result in better urinary incontinence UI outcomes than no treatment.

In stress UI, among interventions commonly used as first- or second-line therapy, behavioral interventions were more effective than alpha agonists and hormones. For the How much does friends reunited dating cost commonly reserved for third-line therapy, it is unclear whether periurethral bulking agents or intravesical pressure release differ in effectiveness.

In urgency UI, among interventions commonly used as first- or second-line, therapy, behavioral interventions were more effective than anticholinergics and hormones. For the interventions commonly reserved for third-line therapy, it is unclear whether onabotulinum toxin A or neuromodulation differ in effectiveness. Dry mouth is the most common side effect, particularly in anticholinergics, but also in alpha agonists, onabotulinum toxin A, pregabalin, and mirabegron.

Serious adverse were rare for all interventions. Onabotulinum toxin A was associated with risk of urinary tract infections and urinary retention. Duloxetine was associated with numerous constitutional adverse effects such as nausea, insomnia, and fatigue.

What about hormone AES? Periurethral bulking agents were associated with erosion or need for surgical removal in a small percentage of women. All of the nonpharmacological interventions, including those that are invasive, generally have few adverse events. Background Urinary incontinence UI is the involuntary loss of urine.

About 17 percent of nonpregnant, adult women are estimated to have UI. The prevalence of UI increases with age, particularly after menopause. The effects of UI range from slightly bothersome to debilitating. The most common types of UI that affect adult women include stress, urgency, and mixed. Stress UI is associated with an inability to retain urine during coughing, sneezing, or other activities that increase intraabdominal pressure.

Urgency UI is defined as the involuntary loss of urine associated with the sensation of a sudden, compelling urge to void that is difficult to defer. Mixed UI occurs when both stress and urgency UI are present. Some causes of UI are amenable to surgical interventions, but we focus only on nonsurgical interventions. Nonpharmacological interventions mostly aim to strengthen the pelvic floor and change behaviors that influence bladder function, whereas pharmacological interventions mostly address bladder and sphincter function.

Table A. It does not imply permanent resolution requiring no further treatment. Table B.

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