Added: Maurita Stockdale - Date: 26.09.2021 01:24 - Views: 10282 - Clicks: 9898
Although it is a multi-functional molecule, its pharmacokinetic characteristics pose restrictions to its use in the treatment of oxidative stress-dependent illnesses. Formulations that increase the bioavailability of a-LA have a better potential efficacy as adjuvants for the treatment of these conditions. This objective was achieved with a liquid formulation for oral use containing only R-aLA, the natural enantiomeric and most active form of a-lipoic acid.
For the first time, the effects of this formulation were evaluated on neuropathic pain, a symptom caused by an increase in oxidative stress, regardless of the underlying cause. Neuropathic patients who have used this dietary supplement noticed an improvement in their quality of life and a ificant reduction was observed in a of certain descriptive pain parameters intensity, burning, unpleasantness, superficial pain.
Undoubtedly further, more in-depth, studies need to be conducted; however, this first investigation confirms the role of R-aLA as an anti-oxidant for the aetiological treatment of peripheral neuropathy. Increasing its plasma bioavailability even after a non-invasive administration through the oral route is a good starting point for proposing a valid adjuvant for the treatment of pain symptoms. Please enable it to take advantage of the complete set of features!
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Salehi B, et al. Brufani M, Figliola R. Brufani M, et al. Acta Biomed. PMID: Review. Alpha lipoic acid and superoxide dismutase in the treatment of chronic low back pain. Battisti E, et al. Eur J Phys Rehabil Med. Epub Jul 9. PMID: Mignini F, et al. Minerva Med. Ikuta N, et al. Int J Mol Sci. See all similar articles. Pacini A, et al. Front Pharmacol. Cai J, et al. Medicine Baltimore. Biological Availability Actions. Humans Actions. Pharmaceutical Solutions Actions. Substances Antioxidants Actions. Thioctic Acid Actions. Copy Download.What is r alpha lipoic acid good for
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Increasing bioavailability of (R)-alpha-lipoic acid to boost antioxidant activity in the treatment of neuropathic pain